Article

Interaction of an α-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease

2022-02-05

Abstract excerpt

<h4>SUMMARY</h4> Enteric symptoms, including constipation, are hallmarks of prodromal Parkinson’s disease (PD) that can appear decades before the onset of motor symptoms and diagnosis. PD patients possess circulating T cells that recognize specific α-synuclein-(α-syn)-derived epitopes. One epitope, α-syn 32-46 , binds with strong affinity to the HLA-DRB1*15:01 allele implicated in autoimmune diseases. We report...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1eb95b0b-3fdb-5909-9d78-30f93b204a39
DOI: 10.1101/2022.02.03.479014

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interaction of an α-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s diseaseDOI 10.1101/2022.02.03.479014Read

Shared Epitope-Positive HLA Alleles Protect Against Alpha-Synuclein Pathology in a Model of Parkinson Disease.Semantic proximity Read

Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathologySemantic proximity Read

Microbiota-dependent T-cell response to α-synuclein-derived antigens triggers the development of hypersensitivity and neuroinflammation associated with Parkinson's DiseaseSemantic proximity Read

Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson’s diseaseSemantic proximity Read

MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulationSemantic proximity Read

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.Semantic proximity Read

PINK1 is a target of T cell responses in Parkinson’s diseaseSemantic proximity Read

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infectionSemantic proximity Read

PINK1 is a target of T cell responses in Parkinson’s diseaseSemantic proximity Read

Adaptive Immunity and Parkinson's Disease.Semantic proximity Read

Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s diseaseSemantic proximity Read

PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infectionSemantic proximity Read