Article

Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinson’s-like gut pathology

2023-10-28

Abstract excerpt

<h4>Summary</h4> Deposition of misfolded α-synuclein (αsyn) in the enteric nervous system (ENS) is found in multiple neurodegenerative diseases. It is hypothesized that ENS synucleinopathy contributes to both the pathogenesis and non-motor morbidity in Parkinson’s Disease (PD), but the cellular and molecular mechanisms that shape enteric histopathology and dysfunction are poorly understood. Here, we demonstrate t...

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Literature Corpus work: 4ebdafd0-ffd2-5fac-a310-7366caec0b86
DOI: 10.1101/2023.10.24.563832

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Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinson’s-like gut pathologyDOI 10.1101/2023.10.24.563832Read

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