Expression of amyloid-β antibody via AAV of CNS tropism alleviates Alzheimer’s disease in mice

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD), the leading cause of dementia, affects over 33 million people worldwide, with pathogenesis tied to amyloid-β (Aβ) accumulation. Although anti-Aβ monoclonal antibodies have shown clinical benefits, they often cause side effects including amyloid-related imaging abnormalities and brain microhemorrhage, especially in APOE E4 allele carriers. Here we used PHP.eB serotype ad...

Topics

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• Age of Onset
• Amyloid beta-Peptides
• Apolipoprotein E2
• Dependovirus
• Gene Transfer Techniques
• Genetic Therapy
• Genetic Vectors
• Molecular Targeted Therapy

Identifiers and source

Literature Corpus work

9cd78989-3c39-56e6-909e-250597783646

DOI

10.64898/2026.03.19.712819