Article

FDA-Approved Passive Immunization Treatments Against Aβ in Alzheimer’s Disease: Where Are We Now?

2025-12-15

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by de-creased amyloid-β clearance, enhanced Aβ aggregation, an increased risk of amy-loid-related imaging abnormalities (ARIA), and blood-brain barrier (BBB) dysfunction. The APOE4 allele, being the leading genetic risk factor for AD, contributes strongly to these symptoms. This review covers the relationship between APOE4 status and the e...

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Literature Corpus work: 2154df72-0bda-56be-aa8f-bc3beb3ca60d
DOI: 10.20944/preprints202512.1248.v1

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