Article

Virus-Mediated Gene Transfer of Soluble Amyloid Precursor Protein-alpha via Systemic Injection in a Mouse Model of Alzheimer's Disease

2025-10-09

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet effective preventive or therapeutic strategies remain limited. A hallmark of AD pathology is the accumulation of insoluble amyloid-β (Aβ) aggregates, which are targeted by recent antibody-based therapies. Conversely, soluble amyloid precursor protein-alpha (sAPPα), a non-amyloidogenic cleavage product of APP, po...

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Literature Corpus work: 667c4a68-2d0f-5841-9cb0-119096a9640c
DOI: 10.21203/rs.3.rs-7615037/v1

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