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Engineered extracellular vesicles targeting BACE1 reduces amyloid-beta plaque formation in a genetic mouse model of Alzheimer’s Disease

2026-08-11

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques, neurodegeneration, and cognitive decline. β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) catalyzes the rate-limiting step in Aβ production and remains a therapeutic target for AD. However, effective delivery of RNA therapeutics to the brain remains challenging due to the blo...

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Literature Corpus work: b2ce5835-306b-5922-9212-ebddb83a5720
DOI: 10.64898/2026.08.10.744066

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