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Characterization of brain transduction capability of a BBB-penetrant, peptide-displaying AAV vector in mice, rats and non-human primates

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>Different screening methods are being developed to generate adeno-associated viral vectors (AAV) with the ability to bypass the blood-brain barrier (BBB) upon intravenous administration. Recently, the AAV9P31 stood out as the most efficient version among a library of peptide-displaying capsids selected in C57BL/6 mice using RNA-driven biopanning. In this work we have characterized in de...

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Literature Corpus work
7a640948-aac3-5a38-9af6-ab62afd312d4
DOI
10.21203/rs.3.rs-4429122/v1
Open publication

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Characterization of brain transduction capability of a BBB-penetrant, peptide-displaying AAV vector in mice, rats and non-human primatesDOI 10.21203/rs.3.rs-4429122/v1
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