Article
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
Neurobiology of aging - 1 Aug 2016
Zhao Lingzhi, Gottesdiener Andrew J, Parmar Mayur, Li Mingjie, Kaminsky Stephen M, Chiuchiolo Maria J, Sondhi Dolan, Sullivan Patrick M, Holtzman David M, Crystal Ronald G, Paul Steven M
Abstract excerpt
The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-onset Alzheimer's disease, with the ε4 allele increasing risk and reducing the age of onset and the ε2 allele decreasing risk and markedly delaying the age of onset. Preclinical and clinical studies have shown that apolipoprotein E (APOE) genotype also predicts the timing and amount of brain amyloid-β (Aβ) peptide...
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