Article

Targeting Soluble Amyloid-Beta Oligomers With a Novel Nanobody

2024-03-15

Abstract excerpt

The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has demonstrated that soluble amyloid-b oligomers (SAbOs) accumulate early, prior to amyloid plaque formation. SAbOs induce memory impairment and disrupt cognitive function independent...

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Literature Corpus work: 1e3f15d4-c337-5505-b81f-835f311a9fcc
DOI: 10.21203/rs.3.rs-3944211/v1

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