Article

AAV mediated delivery of a novel anti-BACE1 VHH reduces Abeta in an Alzheimer’s disease mouse model

2019-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Single domain antibodies (VHH) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHH have not been widely used in the central nervous system (CNS), as it is hard to reach therapeutic levels, both because of their restricted blood-brain-barrier penetration and their apparent rapid clearance from t...

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Literature Corpus work: 1b6903c0-9e4a-5487-b0de-175aa844c506
DOI: 10.1101/698506

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