Article

Enhanced delivery of low-dose of aducanumab via FUS in 5xFAD mice, an AD model

2022-08-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Aducanumab (Adu), which is a human IgG1 monoclonal antibody that targets oligomer and fibril forms of beta-amyloid (Aβ), has been reported to reduce amyloid pathology and improve impaired cognition after the administration of a high dose (10 mg/kg) of the drug in Alzheimer’s disease (AD) clinical trials. The purpose of this study is to investigate the effects of a...

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Literature Corpus work: 5963c15c-cad1-5f1e-b19f-36c3d22eaf77
DOI: 10.21203/rs.3.rs-1891775/v1

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