Article

A side-by-side comparison of variant function measurements using deep mutational scanning and base editing

2024-07-01

Abstract excerpt

Variant annotation is a crucial objective in mammalian functional genomics. Deep Mutational Scanning (DMS) is a well-established method for annotating human gene variants, but CRISPR base editing (BE) is emerging as an alternative. However, questions remain about how well high-throughput base editing measurements can annotate variant function and the extent of downstream experimental validation required. This stud...

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Literature Corpus work: 9cc0ce58-f850-525f-8698-d2d8f49b1594
DOI: 10.1101/2024.06.30.601444

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