Article

Activity-based selection for enhanced base editor mutational scanning

2024-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Base editing is a CRISPR-based technology that enables high-throughput, nucleotide-level functional interrogation of the genome, which is essential for understanding the genetic basis of human disease and informing therapeutic development. Base editing screens have emerged as a powerful experimental approach, yet significant cell-to-cell variability in editing efficiency introduces noise that ma...

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Literature Corpus work: a1aa2202-c95d-5a96-bd94-efeb2543987c
DOI: 10.1101/2024.11.12.622254

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