Article
Annotation and evaluation of base editing outcomes in multiple cell types using CRISPRbase.
Nucleic acids research - 6 Jan 2023
Fan Jibiao, Shi Leisheng, Liu Qi, Zhu Zhipeng, Wang Fan, Song Runxian, Su Jimeng, Zhou Degui, Chen Xiao, Li Kailong, Xue Lixiang, Sun Lichao, Mao Fengbiao
Abstract excerpt
CRISPR-Cas base editing (BE) system is a powerful tool to expand the scope and efficiency of genome editing with single-nucleotide resolution. The editing efficiency, product purity, and off-target effect differ among various BE systems. Herein, we developed CRISPRbase (http://crisprbase.maolab.org), by integrating 1 252 935 records of base editing outcomes in more than 50 cell types from 17 species. CRISPRbase...
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