Article

Enhanced Production of Mesencephalic Dopaminergic Neurons from Lineage-Restricted Human Undifferentiated Stem Cells

2021-09-30

Abstract excerpt

The differentiation of human pluripotent stem cells (hPSCs) into mesencephalic dopaminergic (mesDA) neurons requires a precise combination of extrinsic factors that recapitulates the in vivo environment and timing. Current methods are capable of generating authentic mesDA neurons after long-term culture in vitro ; however, when mesDA progenitors are transplanted in vivo , the resulting mesDA neurons are only mi...

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Literature Corpus work: 9cb09f9e-c994-5afa-9ea0-73ef7f11e6ff
DOI: 10.1101/2021.09.28.462222

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