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Article

Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.

Cell reports - 28 Jun 2012

Kirkeby Agnete, Grealish Shane, Wolf Daniel A, Nelander Jenny, Wood James, Lundblad Martin, Lindvall Olle, Parmar Malin

Abstract excerpt

To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors and neurons from human embryonic stem cells, which recapitulates human fetal brain development. Through the addition of a small molecule that activates canonical WNT signaling, we induced rapid and efficient dose-dependent specification of regionally...

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PMID: 22813745
DOI: 10.1016/j.celrep.2012.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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