Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.

doi:10.1016/j.celrep.2012.04.009

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Article

Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.

Cell reports - 28 Jun 2012

Kirkeby Agnete, Grealish Shane, Wolf Daniel A, Nelander Jenny, Wood James, Lundblad Martin, Lindvall Olle, Parmar Malin

Abstract excerpt

To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors and neurons from human embryonic stem cells, which recapitulates human fetal brain development. Through the addition of a small molecule that activates canonical WNT signaling, we induced rapid and efficient dose-dependent specification of regionally...

Topics

Aging
Animals
Body Patterning
Cell Culture Techniques
Cell Differentiation
Cell Lineage
Cell Proliferation
Cell Survival
Cells, Cultured
Dopamine
Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrophysiological Phenomena

Embryonic Stem Cells

Gene Expression Regulation

Glycogen Synthase Kinase 3

Humans

Motor Activity

Neural Stem Cells

Source

Open in PubMed

Identifiers

PMID: 22813745
DOI: 10.1016/j.celrep.2012.04.009

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