Article

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

2025-11-02

Abstract excerpt

<h4>Summary</h4> In vitro modelling of highly vulnerable nigral dopaminergic (DA) neuronal subtypes in Parkinson’s disease (PD), is necessary for studying disease mechanisms. Here, we optimized a new approach by expressing the pioneer neurogenic transcription factor, Achaete-scute-like 1 ( Ascl1 ), implicated in determining dopaminergic fate. Sequential small-molecule patterning of iPSCs into early floor plate...

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Literature Corpus work: a5d1d806-d2c4-5af7-aa62-97379c3e4df0
DOI: 10.1101/2025.10.31.685897

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