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Article

Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells.

Stem cells (Dayton, Ohio) - 1 Jan 2000

Yan Yiping, Yang Dali, Zarnowska Ewa D, Du Zhongwei, Werbel Brian, Valliere Chuck, Pearce Robert A, Thomson James A, Zhang Su-Chun

Abstract excerpt

How dopamine (DA) neuronal subtypes are specified remains unknown. In this study we show a robust generation of functional DA neurons from human embryonic stem cells (hESCs) through a specific sequence of application of fibroblast growth factor 8 (FGF8) and sonic hedgehog (SHH). Treatment of hESC-derived Sox1+ neuroepithelial cells with FGF8 and SHH resulted in production of tyrosine hydroxylase (TH)-positive...

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Source

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Identifiers

PMID: 15917474
DOI: 10.1634/stemcells.2004-0365
PMCID: PMC2707939

Genes

FGF8
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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