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Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

1 Oct 2016

Abstract excerpt

Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA sequencing to examine ventral midbrain development in human and mouse. We found 25 molecularly defined human cell types, including five subtypes of radial...

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PMID: 27716510
DOI: 10.1016/j.cell.2016.09.027

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