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Directed Dopaminergic Neuron Differentiation from Human Pluripotent Stem Cells

15 Sept 2014

Abstract excerpt

Dopaminergic (DA) neurons in the substantia nigra pars compacta (also known as A9 DA neurons) are the specific cell type that is lost in Parkinson's disease (PD). There is great interest in deriving A9 DA neurons from human pluripotent stem cells (hPSCs) for regenerative cell replacement therapy for PD. During neural development, A9 DA neurons originate from the floor plate (FP) precursors located at the ventral...

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PMID: 25285746
DOI: 10.3791/51737

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