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Article

Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice.

Brain : a journal of neurology - 1 Feb 2010

Corti Stefania, Nizzardo Monica, Nardini Martina, Donadoni Chiara, Salani Sabrina, Ronchi Dario, Simone Chiara, Falcone Marianna, Papadimitriou Dimitra, Locatelli Federica, Mezzina Nicoletta, Gianni Francesca, Bresolin Nereo, Comi Giacomo P

Abstract excerpt

Spinal muscular atrophy, characterized by selective loss of lower motor neurons, is an incurable genetic neurological disease leading to infant mortality. We previously showed that primary neural stem cells derived from spinal cord can ameliorate the spinal muscular atrophy phenotype in mice, but this primary source has limited translational value. Here, we illustrate that pluripotent stem cells from embryonic...

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PMID: 20032086
DOI: 10.1093/brain/awp318

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