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The cIAP ubiquitin ligases sustain type 3 γδ T cells and ILC during aging to promote barrier immunity

23 Jun 2023

Abstract excerpt

Early-life cues shape the immune system during adulthood. However, early-life signaling pathways and their temporal functions are not well understood. Herein, we demonstrate that the cellular inhibitor of apoptosis proteins 1 and 2 (cIAP1/2), which are E3 ubiquitin ligases, sustain interleukin (IL)-17-producing γ δ T cells (γδT17) and group 3 innate lymphoid cells (ILC3) during late neonatal and prepubescent...

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PMID: 37440178
DOI: 10.1084/jem.20221534

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