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Article

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice.

European journal of immunology - 1 Jan 2017

Datta Preeta, Webb Louise M C, Avdo Inxhina, Pascall John, Butcher Geoffrey W

Abstract excerpt

An effective immune system depends upon the survival of mature T cells in the periphery. Members of the GIMAP family of GTPases have been proposed to regulate this homeostasis, supported by the paucity of peripheral T cells in rodents deficient for either GIMAP1 or GIMAP5. It is unclear whether this lack of T cells is a consequence of an ontological defect, causing the thymus to generate and export T cells...

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Source

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Identifiers

PMID: 27792288
DOI: 10.1002/eji.201646599
PMCID: PMC5244661

Genes

GIMAP1
GIMAP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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