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RIP kinases and necroptosis in aging and aging-related diseases

14 Jun 2022

Abstract excerpt

Aging is a natural process that is characterized by chronic, low-grade inflammation, which represents the primary risk factor in the pathogenesis of a variety of diseases, i.e. aging-related diseases. RIP kinases, in particular RIPK1 and RIPK3, have emerged as master regulators of proinflammatory responses that act either by causing apoptosis and necroptosis or by directly regulating intracellular inflammatory...

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PMID: 39872161
DOI: 10.1093/lifemedi/lnac003

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