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Article

Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2017

Sato Kyosuke, Kato Aiko, Sekai Miho, Hamazaki Yoko, Minato Nagahiro

Abstract excerpt

Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with...

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Source

Identifiers

PMID: 28539430
DOI: 10.4049/jimmunol.1602005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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