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Apoptosis Remodeling in Immunosenescence: Implications for Strategies to Delay Ageing

30 May 2007

Abstract excerpt

Immunosenescence is characterized by a peculiar remodeling of the immune system, mainly induced by lifelong antigenic burden and oxidative stress. Apoptosis or programmed cell death plays a central role in the ageing process. Both recurrent antigenic stimulations and oxidative metabolism by-products, impinging upon the immune system, modify the apoptotic capability of lymphocytes, driving immunosenescence. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17584051
DOI: 10.2174/092986707780831122

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