Article

Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds

2021-04-06

Abstract excerpt

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The similar clinical presentation combined with the closed population structure of dogs, leading to high genetic homogenei...

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Literature Corpus work: 9c76c48c-c173-539a-946a-686e109c9583
DOI: 10.1101/2021.04.05.438235

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