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Article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background.

Genome research - 1 Nov 2015

Elvers Ingegerd, Turner-Maier Jason, Swofford Ross, Koltookian Michele, Johnson Jeremy, Stewart Chip, Zhang Cheng-Zhong, Schumacher Steven E, Beroukhim Rameen, Rosenberg Mara, Thomas Rachael, Mauceli Evan, Getz Gad, Palma Federica Di, Modiano Jaime F, Breen Matthew, Lindblad-Toh Kerstin, Alföldi Jessica

Abstract excerpt

Lymphoma is the most common hematological malignancy in developed countries. Outcome is strongly determined by molecular subtype, reflecting a need for new and improved treatment options. Dogs spontaneously develop lymphoma, and the predisposition of certain breeds indicates genetic risk factors. Using the dog breed structure, we selected three lymphoma predisposed breeds developing primarily T-cell (boxer),...

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Identifiers

PMID: 26377837
DOI: 10.1101/gr.194449.115
PMCID: PMC4617960

Genes

POT1
PTEN
TRAF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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