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Genomic analyses identify 15 susceptibility loci and reveal <i>HDAC2</i> , <i>SOX2-OT</i> , and <i>IGF2BP2</i> in a naturally-occurring canine model of gastric cancer

2024-08-16

Abstract excerpt

<h4>SUMMARY</h4> Gastric cancer (GC) is the fifth most common human cancer worldwide, but the genetic etiology is largely unknown. We performed a Bayesian genome-wide association study and selection analyses in a naturally-occurring canine model of GC, the Belgian Tervuren and Sheepdog breeds, to elucidate underlying genetic risk factors. We identified 15 loci with over 90% predictive accuracy for the GC phenotyp...

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Literature Corpus work
52a98a78-2f26-51e0-afe0-7f29961b379f
DOI
10.1101/2024.08.14.604426
Open publication

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Genomic analyses identify 15 susceptibility loci and reveal <i>HDAC2</i> , <i>SOX2-OT</i> , and <i>IGF2BP2</i> in a naturally-occurring canine model of gastric cancerDOI 10.1101/2024.08.14.604426
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