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Article

Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.

PLoS genetics - 1 May 2021

Evans Jacquelyn M, Parker Heidi G, Rutteman Gerard R, Plassais Jocelyn, Grinwis Guy C M, Harris Alexander C, Lana Susan E, Ostrander Elaine A

Abstract excerpt

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The similar clinical presentation combined with the closed population structure of dogs, leading to high genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33983928
DOI: 10.1371/journal.pgen.1009543
PMCID: PMC8118335

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