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Article

Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

19 Mar 2019

Abstract excerpt

BACKGROUND: Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not improved in 50 years. Osteosarcoma still has a 5-year survival rate of 66%. We propose the natural canine osteosarcoma model can change that: it is extremely similar to the human condition, except for being highly heritable and having a dramatically higher incidence. Here we...

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PMID: 30890123
DOI: 10.1186/s12864-019-5531-6

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