Article
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
Genome biology - 12 Dec 2013
Karlsson Elinor K, Sigurdsson Snaevar, Ivansson Emma, Thomas Rachael, Elvers Ingegerd, Wright Jason, Howald Cedric, Tonomura Noriko, Perloski Michele, Swofford Ross, Biagi Tara, Fryc Sarah, Anderson Nathan, Courtay-Cahen Celine, Youell Lisa, Ricketts Sally L, Mandlebaum Sarah, Rivera Patricio, von Euler Henrik, Kisseberth William C, London Cheryl A, Lander Eric S, Couto Guillermo, Comstock Kenine, Starkey Mike P, Modiano Jaime F, Breen Matthew, Lindblad-Toh Kerstin
Abstract excerpt
BACKGROUND: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible. RESULTS: Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest...
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