Article

Canine tumor mutation rate is positively correlated with TP53 mutation across cancer types and breeds

2020-07-15

Abstract excerpt

Spontaneous canine cancers are a valuable but relatively understudied and underutilized model in cancer research. To enhance their usage, we reanalyzed whole exome sequencing data published for 601 dogs with mammary cancer, osteosarcoma, oral melanoma, lymphoma, glioma or hemangiosarcoma from over 35 breeds, after rigorous quality control, including breed validation. Each cancer type harbors distinct molecular fea...

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Literature Corpus work: b088c252-081d-5bff-a3dd-b7714d43680c
DOI: 10.1101/2020.07.15.205286

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