Article

Evaluating the impact of NPC1 SNPs on entry efficiency of Filovirus <i>in vitro</i> : agent-based model approach

2025-03-14

Abstract excerpt

The interaction between the Niemann-Pick C1 (NPC1) protein and the glycoprotein (GP) of filoviruses is essential for viral entry into host cells. Single nucleotide polymorphisms (SNPs) in NPC1, which lead to amino acid substitutions, can significantly alter viral entry efficiency. However, the quantitative impact of these SNPs remains unclear. To address this, we investigate in vitro cell-to-cell infection using a...

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Literature Corpus work: 9c57ec1c-687e-5a01-bccb-bcaf829652be
DOI: 10.1101/2025.03.13.642967

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