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Article

Modeling the efficiency of filovirus entry into cells in vitro: Effects of SNP mutations in the receptor molecule.

PLoS computational biology - 1 Sept 2020

Kim Kwang Su, Kondoh Tatsunari, Asai Yusuke, Takada Ayato, Iwami Shingo

Abstract excerpt

Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However, the dependence of differences in entry efficiency on SNPs remains unclear. Using vesicular stomatitis virus pseudotyped with Ebola and Marburg virus...

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Identifiers

PMID: 32986692
DOI: 10.1371/journal.pcbi.1007612
PMCID: PMC7544041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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