Article

A glycoprotein mutation that emerged during the 2013-2016 Ebola virus epidemic alters proteolysis and accelerates membrane fusion

2020-07-15

Abstract excerpt

Genomic surveillance of viral isolates during the 2013-2016 Ebola virus epidemic in Western Africa—the largest and most devastating filovirus outbreak on record—revealed several novel mutations. The responsible strain, named Makona, carries an A to V substitution at position 82 in the glycoprotein (GP), which is associated with enhanced infectivity in vitro . Here, we investigated the mechanistic basis for this e...

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Literature Corpus work: 4697b541-b2e1-5cfd-bd8b-b8247db50641
DOI: 10.1101/2020.07.13.201863

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