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Article

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.

Nature - 24 Aug 2011

Carette Jan E, Raaben Matthijs, Wong Anthony C, Herbert Andrew S, Obernosterer Gregor, Mulherkar Nirupama, Kuehne Ana I, Kranzusch Philip J, Griffin April M, Ruthel Gordon, Dal Cin Paola, Dye John M, Whelan Sean P, Chandran Kartik, Brummelkamp Thijn R

Abstract excerpt

Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in humans for which no approved antivirals are available. Filovirus entry is mediated by the viral spike glycoprotein (GP), which attaches viral particles to the cell surface, delivers them to endosomes and catalyses fusion between viral and endosomal membranes. Additional host factors in the endosomal compartment are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21866103
DOI: 10.1038/nature10348
PMCID: PMC3175325

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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