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Article

Single-Nucleotide Polymorphisms in Human NPC1 Influence Filovirus Entry Into Cells.

The Journal of infectious diseases - 22 Nov 2018

Kondoh Tatsunari, Letko Michael, Munster Vincent J, Manzoor Rashid, Maruyama Junki, Furuyama Wakako, Miyamoto Hiroko, Shigeno Asako, Fujikura Daisuke, Takadate Yoshihiro, Yoshida Reiko, Igarashi Manabu, Feldmann Heinz, Marzi Andrea, Takada Ayato

Abstract excerpt

Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. It is known that proteolytically digested Ebola virus (EBOV) GP interacts with 2 protruding loops in domain C of NPC1. Using previously published structural data and the National Center for Biotechnology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30010949
DOI: 10.1093/infdis/jiy248
PMCID: PMC6927862

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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