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Article

Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <i>In Vivo</i>

27 May 2015

Abstract excerpt

UNLABELLED: Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated the importance of NPC1, and its partner in cholesterol transport, NPC2, by using a mouse model of Ebolavirus (EBOV)...

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PMID: 26015498
DOI: 10.1128/mbio.00565-15

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