Article

Modeling the efficiency of filovirus entry into cells <i>in vitro</i> : Effects of SNP mutations in the receptor molecule

2019-12-19

Abstract excerpt

Interaction between filovirus glycoprotein (GP) and the Niemann-Pick C1 (NPC1) protein is essential for membrane fusion during virus entry. Some single-nucleotide polymorphism (SNPs) in two surface-exposed loops of NPC1 are known to reduce viral infectivity. However, the dependence of differences in entry efficiency on SNPs remains unclear. Using vesicular stomatitis virus pseudotyped with Ebola and Marburg virus...

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Literature Corpus work: 4fe0e5a3-858d-5704-949f-96a77410bd27
DOI: 10.1101/2019.12.19.882167

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