Article
Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2021
Mouat Margaret A, Coleman James L J, Wu Jianxin, Dos Remedios Cristobal G, Feneley Michael P, Graham Robert M, Smith Nicola J
Abstract excerpt
Multiple mouse lines lacking the orphan G protein-coupled receptor, GPR37L1, have elicited disparate cardiovascular phenotypes. The first Gpr37l1 knockout mice study to be published reported a marked elevation in systolic blood pressure (SBP; ∼60 mmHg), revealing a potential therapeutic opportunity. The phenotype differed from our own independently generated knockout line, where male mice exhibited equivalent...
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