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Article

Magel2 deficiency promotes cardiac remodeling and increases arrhythmogenic susceptibility in a mouse model relevant to Prader-Willi and Schaaf-Yang syndromes.

Clinical science (London, England : 1979) - 15 Jul 2026

Dötsch Laura, Weirauch Leo, Hunger Janika, Thiemann Tobias, Maaß Johann, Schmidt Constanze, Leuschner Florian, Schaaf Christian P, Fröhlich Henning

Abstract excerpt

Prader-Willi syndrome (PWS) and Schaaf-Yang syndrome (SYS) share overlapping phenotypic features, but potential cardiac involvement in both conditions remains poorly understood. Here, we investigated cardiac function in Magel2 knockout (KO) mice, a model relevant to PWS and SYS, to assess the impact of Magel2 deficiency on the heart. Echocardiographic analysis of 20-week-old Magel2-KO mice revealed concentric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42275194
DOI: 10.1042/CS20260647
PMCID: PMC13286937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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