Article

Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice

2022-09-08

Abstract excerpt

Cardiac hypertrophy is necessary for the heart to accommodate an increase in workload. Physiological, compensated hypertrophy (e.g. with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hypertension) is associated with additional features including increased fibrosis and can lead to heart failure. RAF kinases (ARAF/BRAF/RAF1) integrate signals into the ERK1/...

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Literature Corpus work: 06777efd-7e2a-5e62-85cf-570082a0c951
DOI: 10.1101/2022.09.07.506723

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