Article
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.
The Journal of clinical investigation - 1 Jun 2006
Perrino Cinzia, Naga Prasad Sathyamangla V, Mao Lan, Noma Takahisa, Yan Zhen, Kim Hyung-Suk, Smithies Oliver, Rockman Howard A
Abstract excerpt
For over a century, there has been intense debate as to the reason why some cardiac stresses are pathological and others are physiological. One long-standing theory is that physiological overloads such as exercise are intermittent, while pathological overloads such as hypertension are chronic. In this study, we hypothesized that the nature of the stress on the heart, rather than its duration, is the key...
Topics
- Adrenergic beta-Antagonists
- Animals
- Blood Pressure
- Blood Vessels
- Cardiac Output, Low
- Cardiomegaly
- Cells, Cultured
- Echocardiography
- Female
- Gene Expression Regulation
- Heart
- Hemodynamics
- Humans