Article

Cardiac remodeling pathways do not accelerate disease onset and severity in a mouse model of PLN-R14del cardiomyopathy

2025-07-23

Abstract excerpt

<title>Abstract</title> <p>Background: PLN-R14del is a pathogenic Phospholamban (PLN) gene variant, characterized by ventricular arrhythmias and dilated cardiomyopathy in heterozygous carriers. Disease development is highly heterogeneous, indicating involvement of additional disease triggers, influencing both the onset and severity of the disease. Here, a heterozygous PLN-R14del mouse model (R14<sup>Δ/+</sup>) wi...

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Literature Corpus work: 18155291-bca0-53f0-8a28-34ccfd19593a
DOI: 10.21203/rs.3.rs-7019046/v1

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