Article

Old mice have a functionally distinct contractile reserve from obese mice

2025-05-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cardiovascular disease (CVD) is the leading cause of global mortality, with recent increases attributed to demographic shifts in age and rising rates of obesity. Diminished contractile reserve is a hallmark of a diseased heart; assessing contractile reserve is pivotal in prognosticating and monitoring CVD progression. The Frank-Starling mechanism and sympathetic stimulation...

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Literature Corpus work: b1b49799-00b3-5a54-a56d-570f3920e413
DOI: 10.1101/2025.05.13.653770

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