Article

<i>MYH11</i> rare variant augments aortic growth and induces cardiac hypertrophy and heart failure with pressure overload

2024-08-16

Abstract excerpt

Smooth muscle cell-specific myosin heavy chain, encoded by MYH11 , is selectively expressed in smooth muscle cells ( SMC s). Pathogenic variants in MYH11 predispose to a number of disorders, including heritable thoracic aortic disease associated with patent ductus arteriosus, visceral myopathy, and megacystis-microcolon-intestinal hypoperistalsis syndrome. Rare variants of uncertain significance occur throughou...

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Literature Corpus work: 18f13411-fe62-5b5f-bc67-5dbdfb13719e
DOI: 10.1101/2024.08.15.608063

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