Article

Dominant COSMIC Mutational Signatures and Unsupervised Machine Learning Define Mechanism-Based Therapeutic Stratification in Blast-Crisis CML: Implications in precision medicine of relapsed and refractory cancers

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background/Objectives</bold> : Blast-crisis chronic myeloid leukemia (BC-CML) represents a genomically unstable, therapeutically refractory phase driven by clonal evolution beyond BCR::ABL1 dependence. Clinical outcomes remain poor, with median survival under one year. Mutation-level analyses inadequately resolve biological heterogeneity or inform rational patient-specific ther...

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Literature Corpus work: 9c3463dc-83ea-5bbc-9b78-d3ebbe5441a3
DOI: 10.21203/rs.3.rs-10273599/v1

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