Article

Drug-perturbation-based stratification of blood cancer

2017-12-22

Abstract excerpt

As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a prima...

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Literature Corpus work: 88c1ad0f-2b47-5a46-b708-f5cf2ce410d5
DOI: 10.17863/cam.20903

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