Article

Dominant COSMIC Mutational Signatures and Unsupervised Machine Learning Define Mechanism-Based Therapeutic Stratification in Blast-Crisis CML: Implications in Precision Medicine of Relapsed and Refractory Cancers

2026-04-24

Abstract excerpt

<h4>Background: </h4> /Objectives: Blast-crisis chronic myeloid leukemia (BC-CML) represents a genomically unstable, therapeutically refractory phase driven by clonal evolution beyond BCR::ABL1 dependence. Clinical outcomes remain poor, with median survival under one year. Mutation-level analyses inadequately resolve biological heterogeneity or inform rational patient-specific therapy. We therefore implemented a m...

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Literature Corpus work: 2fd89332-d9d6-5ff0-8b8b-1337907e0587
DOI: 10.20944/preprints202604.1729.v1

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Dominant COSMIC Mutational Signatures and Unsupervised Machine Learning Define Mechanism-Based Therapeutic Stratification in Blast-Crisis CML: Implications in Precision Medicine of Relapsed and Refractory CancersDOI 10.20944/preprints202604.1729.v1Read

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